CRASH 2&3 Trial

Summary by Tarek Elshazly MD, 04.18.22

Take Home Point:

CRASH 2 - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60835-5/fulltext

  • Tranexamic acid safely reduced the risk of death in bleeding trauma patients (most effective when given early after the trauma and should be given only within approximately 3 hours.)

CRASH 3 - https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32233-0/fulltext

  • Tranexamic acid is safe in patients with TBI and that treatment within 3 h of injury reduces head injury-related death.